L-homoarginine

Three steps

• oxalic acidReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:17380Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC25A2, SLC7A6, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Ornithine:2-oxo-acid aminotransferase
  3. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)

  Catalysed by SLC25A2, OAT, ALDH4A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• AH2Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• S-methyl-5'-thioadenosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by SLC25A2, ODC1, SRMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC25A2, GATM, ALAS1, ALAS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• nitrateReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  3. Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate

  Catalysed by SLC25A29, NOS3, NOS1, NOS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• indole-3-pyruvateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC25A2, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, AARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycine betaineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:17769Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. Putrescine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, ODC1, AOC2, AOC1 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes

• trans-urocanateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, HALinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• urateReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-Arginine amidinohydrolase
  3. Peroxidase

  Catalysed by SLC25A29, ARG1, MPOinner side of the membrane, outer side of the membrane, cytosol, nucleusOne of 3 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC25A2, SLC7A6, GOT2, TATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A29, ASLinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by SLC25A2, SLC7A6, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A29, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol

• 2-phenylethylamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC25A2, SLC7A6, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A6, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ophthalmateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A8inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• biocytinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC25A2, SLC25A15, BTDinner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC25A2, GATM, AGXT2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A29, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC25A2, GATM, SHMT1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC25A2, SLC7A6, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC25A2, GATM, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC25A29, SLC6A14, LPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC12A2, SLC12A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC25A2, GATM, GLYATinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. LTD4 hydrolysis

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A2, SLC7A6, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC25A29, SLC7A9, CTHinner side of the membrane, outer side of the membrane, cytosol

• N-acetyl-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC25A2, SLC7A6, NAGSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A2, SLC7A6, SLC1A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, CARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, FARSB, FARSAinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC25A2, GATM, GARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, WARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, IARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, QARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• isocyanateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC25A2, SLC7A9, LACC1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, NARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycocholateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol, peroxisomeOne of 3 routes