15-oxoprostaglandin F2alpha

Three steps

• D-serineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by LDHB, LDHAL6B, SRRextracellular space, cytosol, mitochondrial matrix

• chenodeoxycholateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• taurocholateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 6 routes

• glycolithocholic acidReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (R)-lactic acidReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHB, LDHAL6B, LDHDextracellular space, cytosol, mitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetoacetate and L-lactate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by LDHB, LDHAL6B, RIDAextracellular space, cytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by LDHB, LDHAL6B, PKM, PKLRextracellular space, cytosol, mitochondrial matrix

• 13-cis-retinalReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of L-lactate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by LDHB, LDHAL6B, NPLextracellular space, cytosol, mitochondrial matrix

• N-(acetyl)-sphing-4-enineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO2A1, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• malonaldehydeReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by TBXAS1cytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by LDHB, LDHAL6B, FAHD1extracellular space, cytosol, mitochondrial matrix

• acetoacetyl-CoAReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetoacetate and L-lactate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes

• butanoyl-CoAReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of butyrate and L-lactate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 8 moreextracellular space, cytosolOne of 2 routes

• glutaryl-CoAReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLC22A8, SUGCTcytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin E1Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• 15-oxoprostaglandin E2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. carbonyl reductase (NADPH) (prostaglandin F2alpha)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by CBR3, CBR1, AKR1C3, DHRS4 and 1 morecytosolOne of 2 routes

• 15-oxoprostaglandin D2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. aldo-keto reductase (prostaglandin D2)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by AKR1C3cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular space

• thromboxane A2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. thromboxane A synthase (prostaglandin H2)

  Catalysed by TBXAS1cytosol, endoplasmic reticulumOne of 2 routes

• leukotriene A4Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by CYB5D1extracellular space, cytosol, mitochondrial matrix

• (R)-S-lactoylglutathioneReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO2A1, GLO1, GLOD4cytosol, extracellular spaceOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by LDHB, LDHAL6B, MPSTextracellular space, cytosol, mitochondrial matrix

• S-formylglutathioneReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 morecytosol, extracellular space

• 2-methyl-3-oxopropanoateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• 3',5'-cyclic GMPReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by LDHB, LDHAL6B, TYW1B, TYW1extracellular space, cytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• glutathioneReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by SLC22A12, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-alanineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 18 routes

• leukotriene C4Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• 3',5'-cyclic AMPReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-acetylputrescineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• glutathione disulfideReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• kynurenateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• N(8)-acetylspermidineReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• (3S)-citramalyl-CoAReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by LDHB, LDHAL6B, CLYBLextracellular space, cytosol, mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• S-sulfanylglutathioneReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO2A1, SQORcytosol, extracellular space, mitochondrial matrix

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes