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Proteins/UNIPROT:P16152
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue..
Function from UniProtKB (P16152), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
415 statements
415 statements · 8 reference databases · Subject: CBR1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
45 reactions
12 names
Resolves to: CBR1
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR00980CC BY 4.0Reference data
MAM02364c+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184cytosol
Human-GEM MAR01100CC BY 4.0Reference data
MAM02364m+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01102CC BY 4.0Reference data
MAM02364x+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01105CC BY 4.0Reference data
MAM00328c+NADP(3-)MAM00329c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01116CC BY 4.0Reference data
MAM00328r+NADP(3-)MAM00329r+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184endoplasmic reticulum
Human-GEM MAR01117CC BY 4.0Reference data
MAM00254c+NADP(3-)MAM00333c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01123CC BY 4.0Reference data
MAM00254m+NADP(3-)MAM00333m+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01124CC BY 4.0Reference data
MAM00254x+NADP(3-)MAM00333x+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01125CC BY 4.0Reference data
MAM01124c+proton+NADPH(4-)MAM01172c+NADP(3-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01146CC BY 4.0Reference data
MAM01124m+proton+NADPH(4-)MAM01172m+NADP(3-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01147CC BY 4.0Reference data