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Proteins/UNIPROT:O75828
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified..
Function from UniProtKB (O75828), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
301 statements
301 statements · 6 reference databases · Subject: CBR3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
36 reactions
4 names
Resolves to: CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR00980CC BY 4.0Reference data
MAM02364c+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184cytosol
Human-GEM MAR01100CC BY 4.0Reference data
MAM02364m+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01101CC BY 4.0Reference data
MAM02364m+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01102CC BY 4.0Reference data
MAM02364r+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184endoplasmic reticulum
Human-GEM MAR01103CC BY 4.0Reference data
MAM02364x+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01105CC BY 4.0Reference data
MAM02364x+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01106CC BY 4.0Reference data
MAM00328c+NADP(3-)MAM00329c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01116CC BY 4.0Reference data
MAM00328r+NADP(3-)MAM00329r+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184endoplasmic reticulum
Human-GEM MAR01117CC BY 4.0Reference data
MAM00254c+NADP(3-)MAM00333c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01123CC BY 4.0Reference data
MAM00254m+NADP(3-)MAM00333m+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01124CC BY 4.0Reference data