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Proteins/UNIPROT:Q9BTZ2
NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. Displays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals. In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds..
[Isoform 7]: No detected catalytic activity in vitro, possibly due to the lack of catalytic site..
[Isoform 8]: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification..
Function from UniProtKB (Q9BTZ2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
77 statements
77 statements · 7 reference databases · Subject: DHRS4 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
48 reactions
12 names
Resolves to: DHRS4
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR00980CC BY 4.0Reference data
MAM02364c+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184cytosol
Human-GEM MAR01100CC BY 4.0Reference data
MAM02364m+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01101CC BY 4.0Reference data
MAM02364m+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01102CC BY 4.0Reference data
MAM02364r+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184endoplasmic reticulum
Human-GEM MAR01103CC BY 4.0Reference data
MAM02364x+NADP(3-)12-oxo-leukotriene B4+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageLeft to rightBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01105CC BY 4.0Reference data
MAM02364x+NAD(+)12-oxo-leukotriene B4+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.184peroxisome
Human-GEM MAR01106CC BY 4.0Reference data
MAM00328c+NADP(3-)MAM00329c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01116CC BY 4.0Reference data
MAM00328r+NADP(3-)MAM00329r+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184endoplasmic reticulum
Human-GEM MAR01117CC BY 4.0Reference data
MAM00254c+NADP(3-)MAM00333c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR01123CC BY 4.0Reference data
MAM00254m+NADP(3-)MAM00333m+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR01124CC BY 4.0Reference data