Compound

15-oxoprostaglandin E2

Conjugate base of 15-dehydro-prostaglandin E2.

Definition from ChEBI (CHEBI:57400), read 2026-09-23. CC BY 4.0.

CHEBI:57400ChEBI

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Structure

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A generated conformer of 15-oxoprostaglandin E2 — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C20H29O5
Mass: 349.447 g/mol
Charge: -1
InChIKey: YRTJDWROBKPZNV-KMXMBPPJSA-M
SMILES: CCCCCC(=O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=CCCCC(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: 15-oxoprostaglandin E2 · Sources: Human-GEM, Rhea

Order

13,14-dihydro-15-oxo-prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundHuman-GEM MAR20019Inferred only
13,14-dihydro-15-oxo-prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundHuman-GEM MAR20018Inferred only
prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundRhea RHEA:11876Inferred only
prostaglandin E2 is converted to 15-oxoprostaglandin E2CompoundRhea RHEA:63476Inferred only
15-oxoprostaglandin E2 is converted to prostaglandin E2CompoundRhea RHEA:11876Inferred only
15-oxoprostaglandin E2 is converted to prostaglandin E2CompoundRhea RHEA:63476Inferred only
15-oxoprostaglandin E2 is a substrate of CBR1ProteinRhea RHEA:63476Inferred only
15-oxoprostaglandin E2 is a substrate of HPGDProteinRhea RHEA:11876Inferred only

Reactions

6 reactions

NADP(3-)+13,14-dihydro-15-oxo-prostaglandin E2proton+NADPH(4-)+15-oxoprostaglandin E2
Catalysed by PTGR3
Reaction pageLeft to rightBalancedEC 1.3.1.48GO:0005794
Human-GEM MAR20018CC BY 4.0Reference data
NADP(3-)+13,14-dihydro-15-oxo-prostaglandin E2proton+NADPH(4-)+15-oxoprostaglandin E2
Catalysed by PTGR3
Reaction pageLeft to rightBalancedEC 1.3.1.48GO:0005634
Human-GEM MAR20019CC BY 4.0Reference data
prostaglandin E2+NAD(1-)15-oxoprostaglandin E2+NADH(2-)+hydron
Catalysed by HPGD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11876CC BY 4.0Reference data
13,14-dihydro-15-oxo-prostaglandin E2+NADP(3-)15-oxoprostaglandin E2+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:11912CC BY 4.0Reference data
13,14-dihydro-15-oxo-prostaglandin E2+NAD(1-)15-oxoprostaglandin E2+NADH(2-)+hydron
Catalysed by PTGR2
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:11916CC BY 4.0Reference data
prostaglandin E2+NADP(3-)15-oxoprostaglandin E2+NADPH(4-)+hydron
Catalysed by CBR1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:63476CC BY 4.0Reference data

Other names

6 names

Resolves to: 15-oxoprostaglandin E2

Also called: 15-dehydro-prostaglandin E2 anion15-keto-PGE215-oxo-PGE215-oxo-prostaglandin E2
Systematic name: (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate(5Z,13E)-11α-hydroxy-9,15-dioxoprosta-5,13-dienoate