Loading the page.
Proteins/UNIPROT:Q9NVE7
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels (Probable)..
Function from UniProtKB (Q9NVE7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
79 statements
79 statements · 6 reference databases · Subject: PANK4 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
water+pantetheine 4'-phosphate(R)-pantetheine+phosphate(3-)
Catalysed by PANK4
Reaction pageLeft to rightBalancedEC 3.1.3.110cytosol
Human-GEM MAR08792CC BY 4.0Reference data
(R)-4'-phosphopantetheine+water(R)-pantetheine+hydrogenphosphate
Catalysed by PANK4
Reaction pageLeft to rightBalanced
2 names
Resolves to: PANK4
CHEBI:177300+waterCHEBI:177301+hydrogenphosphate
Catalysed by PANK4
Reaction pageLeft to rightBalanced
Rhea RHEA:68336CC BY 4.0Reference data
CHEBI:177302+waterCHEBI:177303+hydrogenphosphate
Catalysed by PANK4
Reaction pageLeft to rightBalanced
Rhea RHEA:68340CC BY 4.0Reference data