Loading the page.
Proteins/UNIPROT:Q14457
Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense..
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors..
(Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus..
Function from UniProtKB (Q14457), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
409 statements
409 statements · 4 reference databases · Subject: BECN1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
4 names
Resolves to: BECN1