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Proteins/UNIPROT:Q8IY47
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation..
Function from UniProtKB (Q8IY47), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
35 statements
35 statements · 2 reference databases · Subject: KBTBD2 · Sources: gene ontology, Hetionet
4 names
Resolves to: KBTBD2