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Proteins/UNIPROT:Q9UBM1
Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step. Responsible for approximately 30% of hepatic PC with the CDP-choline pathway accounting for the other 70% (Probable)..
[Isoform 1]: Catalyzes the three sequential steps of the methylation of 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine (PMME) to 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine (PDME) more efficiently than isoform 2. Induces increase in PC species with longer polyunsaturated chains than isoform 2..
[Isoform 2]: Produces a higher increase in the level of PC species containing long chains with three double bonds than isoform 1..
Function from UniProtKB (Q9UBM1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
88 statements
88 statements · 7 reference databases · Subject: PEMT · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
24 reactions
phosphatidylethanolamine+S-adenosyl-L-methionineproton+MAM02686c+CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17cytosol
Human-GEM MAR00653CC BY 4.0Reference data
MAM02686c+S-adenosyl-L-methionineproton+MAM02758c+CHEBI:16680
Catalysed by PEMT
6 names
Resolves to: PEMT
Human-GEM MAR00654CC BY 4.0Reference data
MAM02758c+S-adenosyl-L-methionineproton+1,2-diacyl-sn-glycero-3-phosphocholine(1+)+CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17cytosol
Human-GEM MAR00657CC BY 4.0Reference data
phosphatidylethanolamine+3S-adenosyl-L-methionine3proton+1,2-diacyl-sn-glycero-3-phosphocholine(1+)+3CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17mitochondrial matrix
Human-GEM MAR01603CC BY 4.0Reference data
phosphatidylethanolamine+3S-adenosyl-L-methionine3proton+1,2-diacyl-sn-glycero-3-phosphocholine(1+)+3CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17endoplasmic reticulum
Human-GEM MAR01606CC BY 4.0Reference data
S-adenosyl-L-methionine+MAM03316m2proton+CHEBI:16680+MAM03321m
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17mitochondrial matrix
Human-GEM MAR02483CC BY 4.0Reference data
S-adenosyl-L-methionine+MAM03316r2proton+CHEBI:16680+MAM03321r
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17endoplasmic reticulum
Human-GEM MAR02485CC BY 4.0Reference data
S-adenosyl-L-methionine+MAM03321m1,2-diacyl-sn-glycero-3-phosphocholine(1+)+CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17mitochondrial matrix
Human-GEM MAR03902CC BY 4.0Reference data
S-adenosyl-L-methionine+MAM03321r1,2-diacyl-sn-glycero-3-phosphocholine(1+)+CHEBI:16680
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.17endoplasmic reticulum
Human-GEM MAR03904CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine+S-adenosyl-L-methioninea 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine+S-adenosyl-L-homocysteine+hydron
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11164CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine+S-adenosyl-L-methioninea 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine+S-adenosyl-L-homocysteine+hydron
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32735CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine+S-adenosyl-L-methioninea 1,2-diacyl-sn-glycero-3-phosphocholine+S-adenosyl-L-homocysteine+hydron
Catalysed by PEMT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32739CC BY 4.0Reference data