Proteins/UNIPROT:P78369

CLDN10

ProteinUNIPROT:P78369Claudin-105 compounds

Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability..

[Isoform 1]: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function..

[Isoform 2]: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis..

Function from UniProtKB (P78369), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 5 · transported by

What routes through it

5 compounds

5 compounds.

0 reported routes5 assembled routes

What the reference databases state

GenCC submitters' classifications

1 row

HELIX syndrome has a germline basis in CLDN10DiseaseGenCC HGNC:2033|MONDO:0060564Inferred only

Statements

32 statements

32 statements · 7 reference databases · Subject: CLDN10 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways

Order

CLDN10 is expressed in body of pancreasAnatomyBgee ENSG00000134873Inferred only
CLDN10 is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000134873Inferred only
CLDN10 is expressed in nephron tubuleAnatomyBgee ENSG00000134873Inferred only
CLDN10 is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000134873Inferred only
CLDN10 is expressed in pancreatic ductal cellCell typeBgee ENSG00000134873Inferred only
CLDN10 is expressed in parotid glandAnatomyBgee ENSG00000134873Inferred only
CLDN10 is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000134873Inferred only
CLDN10 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000134873Inferred only
CLDN10 interacts with VKORC1ProteinHetionet hetionet:interacts:79001-9071Inferred only
CLDN10 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
CLDN10 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
CLDN10 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only

Show the remaining 20

CLDN10 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CLDN10 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
CLDN10 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
CLDN10 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
CLDN10 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
CLDN10 participates in Tight junction interactionsPathwayReactome R-HSA-420029Inferred only
CLDN10 regulates regulation of monoatomic ion transportBiological processgene ontology P78369|GO:0043269Inferred only
MSRA decreases the expression of CLDN10ProteinHetionet hetionet:regulates:4482-9071Inferred only
NRAS decreases the expression of CLDN10ProteinHetionet hetionet:regulates:4893-9071Inferred only
ammonium is transported by CLDN10CompoundRhea RHEA:28747Inferred only
Ca(2+) is transported by CLDN10CompoundRhea RHEA:29671Inferred only
chloride is transported by CLDN10CompoundRhea RHEA:29823Inferred only
Cs(+) is transported by CLDN10CompoundRhea RHEA:78555Inferred only
K(+) is transported by CLDN10CompoundRhea RHEA:29463Inferred only
Li(+) is transported by CLDN10CompoundRhea RHEA:78551Inferred only
magnesium(2+) is transported by CLDN10CompoundRhea RHEA:29827Inferred only
methylamine is transported by CLDN10CompoundRhea RHEA:74391Inferred only
nitrate is transported by CLDN10CompoundRhea RHEA:34923Inferred only
Rb(+) is transported by CLDN10CompoundRhea RHEA:78547Inferred only
sodium(1+) is transported by CLDN10CompoundRhea RHEA:34963Inferred only

Reactions

12 reactions

ammoniumammonium
Transported by KCNK1 or AQP9 or CNGA1 or CHRNA7 or CLDN15 or CLDN10 or RHAG or AQP6 or CNGB1 or CNGA2 or CNGA3 or CNGA4 and 4 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:28747CC BY 4.0Reference data

Other names

2 names

Resolves to: CLDN10

Also called: Oligodendrocyte-specific protein-likeOSP-like

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Element

CHEBI:29103

Inferred only9 paths9 endpoints

magnesium(2+)ElementCHEBI:18420Inferred only9 paths9 endpoints

nitrateCompoundCHEBI:17632Inferred only9 paths9 endpoints

sodium(1+)ElementCHEBI:29101Inferred only9 paths9 endpoints

K(+)

Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:29463CC BY 4.0Reference data

Ca(2+)Ca(2+)

Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives

Reaction pageRight to leftBalanced

Rhea RHEA:29671CC BY 4.0Reference data

chloridechloride

Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives

Reaction pageRight to leftBalanced

Rhea RHEA:29823CC BY 4.0Reference data

magnesium(2+)magnesium(2+)

Transported by TMEM150C or TRPA1 or VDAC1 or GRIA1 or HTR3A or GRIA4 or CLDN10 or NIPAL4 or TMEM63B or NIPAL1 or NIPA1 or PKD1L3 and 17 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:29827CC BY 4.0Reference data

nitratenitrate

Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:34923CC BY 4.0Reference data

sodium(1+)sodium(1+)

Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives

Reaction pageRight to leftBalanced

Rhea RHEA:34963CC BY 4.0Reference data

methylaminemethylamine

Transported by AQP8 or CLDN15 or CLDN2 or CLDN10 or RHAG or RHBG or RHCG

Reaction pageLeft to rightBalanced

Rhea RHEA:74391CC BY 4.0Reference data

Rb(+)Rb(+)

Transported by KCNK1 or KCNQ3 or KCNQ2 or KCNK2 or CNGA1 or CLDN15 or CLDN2 or KCNK10 or CLDN10 or CNGB1 or CNGA2 or CNGA3 and 8 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:78547CC BY 4.0Reference data

Li(+)Li(+)

Transported by KCNK1 or CNGA1 or GRIA1 or TRPC1 or CLDN15 or CLDN2 or ASIC1 or CLDN10 or CNGB1 or CNGA2 or CNGA3 or ASIC2 and 7 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:78551CC BY 4.0Reference data

Cs(+)Cs(+)

Transported by KCNK1 or KCNQ3 or KCNQ2 or KCNK2 or CNGA1 or TRPC1 or CLDN15 or CLDN2 or KCNK10 or CLDN10 or CNGB1 or CNGA2 and 12 more alternatives

Reaction pageDirection not assertedBalanced

Rhea RHEA:78555CC BY 4.0Reference data

CHEBI:35104CHEBI:35104

Transported by GRIA1 or CLDN10

Reaction pageDirection not assertedBalanced

Rhea RHEA:78679CC BY 4.0Reference data