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Proteins/UNIPROT:Q99519
Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage..
Function from UniProtKB (Q99519), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
104 statements
104 statements · 4 reference databases · Subject: NEU1 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
37 reactions
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+
7 names
Resolves to: NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00826CC BY 4.0Reference data
water+a ganglioside GM4 (d18:1(4E))CHEBI:12947+proton+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00834CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00845CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00847CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
water+MAM02259lMAM02270l+N-acetyl-beta-neuraminic acid
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07378CC BY 4.0Reference data
water+MAM02270lproton+MAM02273l+sulfate
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07379CC BY 4.0Reference data
2water+MAM02273l2alpha-D-galactose+MAM02274l
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07380CC BY 4.0Reference data
water+MAM02276lalpha-D-galactose+MAM02277l
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07384CC BY 4.0Reference data
water+MAM02239lalpha-D-galactose+MAM02240l
Catalysed by CTSA & GLB1 & GALNS & NEU1
Reaction pageLeft to rightBalancedEC 3.1.6.4, 3.2.1.18, 3.2.1.23, 3.4.16.5lysosome
Human-GEM MAR07388CC BY 4.0Reference data