Loading the page.
Proteins/UNIPROT:P09601
[Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis..
[Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy..
[Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron..
Function from UniProtKB (P09601), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
618 statements
618 statements · 8 reference databases · Subject: HMOX1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
5proton+heme b+3NADPH(4-)+3dioxygenbiliverdin IXalpha+CO+iron(2+)+3water+3NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.14.18cytosol
Human-GEM MAR01450CC BY 4.0Reference data
3
4 names
Resolves to: HMOX1
Reaction pageLeft to rightUnbalancedEC 1.14.14.18cytosol
Human-GEM MAR04763CC BY 4.0Reference data
heme b+3reduced [NADPH--hemoprotein reductase]+3dioxygenbiliverdin IXalpha+CO+iron(2+)+3oxidized [NADPH--hemoprotein reductase]+3water+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21764CC BY 4.0Reference data