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Proteins/UNIPROT:P18031
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET..
Function from UniProtKB (P18031), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
496 statements
496 statements · 4 reference databases · Subject: PTPN1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
1 reaction
3 names
Resolves to: PTPN1