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Proteins/UNIPROT:P30048
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength (By similarity)..
Function from UniProtKB (P30048), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
302 statements
302 statements · 8 reference databases · Subject: PRDX3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
10 names
Resolves to: PRDX3
Human-GEM MAR04116CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29mitochondrial matrix
Human-GEM MAR04121CC BY 4.0Reference data
a hydroperoxide+[thioredoxin]-dithiolan alcohol+[thioredoxin]-disulfide+water
Catalysed by PRDX5 or PRDX3 or PRDX2 or PRDX1 or PRDX4
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62620CC BY 4.0Reference data