Proteins/UNIPROT:O94923

GLCE

ProteinUNIPROT:O94923

Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins..

Function from UniProtKB (O94923), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 4 reference databases · Subject: GLCE · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GLCE covaries with EXOC8ProteinHetionet hetionet:covaries:149371-26035Inferred only
MGAT4B covaries with GLCEProteinHetionet hetionet:covaries:11282-26035Inferred only
NHLRC4 covaries with GLCEProteinHetionet hetionet:covaries:26035-283948Inferred only
RHBDL1 covaries with GLCEProteinHetionet hetionet:covaries:26035-9028Inferred only
UBC interacts with GLCEProteinHetionet hetionet:interacts:26035-7316Inferred only
GLCE participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
GLCE participates in Glycosaminoglycan synthesis in fibroblastsPathwayWikiPathways WP5395Inferred only
GLCE participates in Heparan sulfate/heparin (HS-GAG) metabolismPathwayReactome R-HSA-1638091Inferred only
GLCE participates in HS-GAG biosynthesisPathwayReactome R-HSA-2022928Inferred only
GLCE participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GLCE participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
GLCE regulates negative regulation of cell projection organizationBiological processgene ontology O94923|GO:0031345Inferred only

Show the remaining 7

GLCE regulates positive regulation of cell population proliferationBiological processgene ontology O94923|GO:0008284Inferred only
GLCE regulates positive regulation of SMAD protein signal transductionBiological processgene ontology O94923|GO:0060391Inferred only
ASL decreases the expression of GLCEProteinHetionet hetionet:regulates:435-26035Inferred only
MSRA decreases the expression of GLCEProteinHetionet hetionet:regulates:4482-26035Inferred only
POLD1 increases the expression of GLCEProteinHetionet hetionet:regulates:5424-26035Inferred only
PTPN1 increases the expression of GLCEProteinHetionet hetionet:regulates:5770-26035Inferred only
SETMAR increases the expression of GLCEProteinHetionet hetionet:regulates:6419-26035Inferred only

Reactions

2 reactions

MAM02082gMAM02083g
Catalysed by GLCE
Reaction pageLeft to rightBalance undeterminableEC 5.1.3.17Golgi apparatus
Human-GEM MAR07217CC BY 4.0Reference data
[heparosan-N-sulfate](n)[heparan-N-sulfate](n)
Catalysed by GLCE
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20197CC BY 4.0Reference data

Other names

5 names

Resolves to: GLCE

Also called: Heparan sulfate C5-epimeraseHeparin/heparan sulfate:glucuronic acid C5-epimeraseHeparosan-N-sulfate-glucuronate 5-epimeraseHsepiKIAA0836

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