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Proteins/UNIPROT:Q8TB40
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine..
Function from UniProtKB (Q8TB40), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
318 statements
318 statements · 3 reference databases · Subject: ABHD4 · Sources: Hetionet, Reactome, Rhea · Rows fetched: 300
10 reactions
N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45384CC BY 4.0Reference data
N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-octadecanoyl-sn-glycero-3-phospho-ethanolamine+(9Z)-octadecenoate+hydron
4 names
Resolves to: ABHD4
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45388CC BY 4.0Reference data
N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-eicosanoyl-sn-glycero-3-phosphoethanolamine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45392CC BY 4.0Reference data
N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45396CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45400CC BY 4.0Reference data
N,1-diacyl-sn-glycero-3-phosphoethanolamine+waterN-acyl-sn-glycero-3-phosphoethanolamine+a fatty acid+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45420CC BY 4.0Reference data
N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G1B or PLA2G2A or PLA2G5 or ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:45424CC BY 4.0Reference data
an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine+waterN,1-diacyl-sn-glycero-3-phosphoethanolamine+a fatty acid+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45460CC BY 4.0Reference data
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine+water1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:55236CC BY 4.0Reference data
1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine+water1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine+(9Z)-octadecenoate+hydron
Catalysed by ABHD4
Reaction pageLeft to rightBalanced
Rhea RHEA:55240CC BY 4.0Reference data