Loading the page.
Proteins/UNIPROT:Q16665
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia..
(Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state. In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons. Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response..
Function from UniProtKB (Q16665), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
343 statements
343 statements · 5 reference databases · Subject: HIF1A · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways · Rows fetched: 300
1 reaction
2-oxoglutarate(2-)+isocitric acid2-oxoglutarate(2-)+isocitric acid
Transported by HIF1A
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR00713CC BY 4.0Reference data
10 names
Resolves to: HIF1A