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Proteins/UNIPROT:P04035
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs..
Function from UniProtKB (P04035), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
202 statements
202 statements · 8 reference databases · Subject: HMGCR · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
2proton+CHEBI:15467+2NADPH(4-)MAM00167c+CHEBI:1146900+2NADP(3-)
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.34cytosol
Human-GEM MAR01440CC BY 4.0Reference data
2proton+CHEBI:15467+2NADPH(4-)MAM00167r+CHEBI:1146900
1 name
Resolves to: HMGCR
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.88endoplasmic reticulum
Human-GEM MAR01446CC BY 4.0Reference data
2proton+CHEBI:15467+2NADPH(4-)MAM00167x+CHEBI:1146900+2NADP(3-)
Catalysed by HMGCR
Reaction pageLeft to rightBalancedEC 1.1.1.34peroxisome
Human-GEM MAR04630CC BY 4.0Reference data
(R)-mevalonate+2NADP(3-)+coenzyme A(4-)(3S)-3-hydroxy-3-methylglutaryl-CoA+2NADPH(4-)+2hydron
Catalysed by HMGCR
Reaction pageRight to leftBalanced
Rhea RHEA:15989CC BY 4.0Reference data