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Proteins/UNIPROT:P15291
Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans. Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms. Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions. Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine. With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose..
[Isoform Long]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, like those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Acts as a sperm receptor for ZP3 O-linked glycans on the zona pellucida leading to activation of G protein signaling and acrosome reaction..
[Processed beta-1,4-galactosyltransferase 1]: The secreted form is proficient in galactosyltransferase activity and could be involved in glycan remodeling in biological fluids..
Function from UniProtKB (P15291), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
343 statements
343 statements · 9 reference databases · Subject: B4GALT1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
55 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
13 names
Resolves to: B4GALT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+CHEBI:67119proton+a neolactoside nLc4Cer(d18:1(4E))+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT4 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00875CC BY 4.0Reference data
MAM02593c+CHEBI:67119proton+MAM02594c+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT4 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00890CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data
MAM01829g+2CHEBI:671192proton+MAM02323g+2UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.38Golgi apparatus
Human-GEM MAR07333CC BY 4.0Reference data
MAM02212g+CHEBI:67119proton+MAM02223g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07337CC BY 4.0Reference data
MAM02232g+CHEBI:67119proton+MAM02233g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07340CC BY 4.0Reference data
MAM02235g+CHEBI:67119proton+MAM02236g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07343CC BY 4.0Reference data
MAM02203g+CHEBI:67119proton+MAM02204g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07346CC BY 4.0Reference data
MAM02206g+CHEBI:67119proton+MAM02207g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07349CC BY 4.0Reference data