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Proteins/UNIPROT:O43488
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen..
Function from UniProtKB (O43488), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
661 statements
661 statements · 7 reference databases · Subject: AKR7A2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
9 reactions
MAM01294c+2protonMAM00229c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07025CC BY 4.0Reference data
MAM00229c+3protonMAM01156c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07026CC BY 4.0Reference data
8 names
Resolves to: AKR7A2
MAM01294c+2protonMAM01318c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07027CC BY 4.0Reference data
MAM01318c+3protonMAM01156c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07028CC BY 4.0Reference data
proton+MAM02337c+NADPH(4-)L-arabinitol+NADP(3-)
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08341CC BY 4.0Reference data
proton+methylglyoxal+NADPH(4-)hydroxyacetone+NADP(3-)
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08497CC BY 4.0Reference data
proton+hydroxyacetone+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08500CC BY 4.0Reference data
(R)-lactaldehyde+proton+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2cytosol
Human-GEM MAR08509CC BY 4.0Reference data
4-hydroxybutanoate+NADP(3-)succinate semialdehyde+NADPH(4-)+hydron
Catalysed by AKR7A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:26381CC BY 4.0Reference data