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Proteins/UNIPROT:P33316
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity)..
Function from UniProtKB (P33316), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
203 statements
203 statements · 6 reference databases · Subject: DUT · Sources: gene ontology, Hetionet, Human-GEM, Rhea, UniProt, WikiPathways
4 reactions
MAM01754c+waterdUMP+proton+phosphate(3-)
Catalysed by DUT
Reaction pageLeft to rightBalancedEC 3.6.1.23cytosol
Human-GEM MAR03965CC BY 4.0Reference data
dUTP+waterdUMP+proton+diphosphate(3-)
Catalysed by DUT
Reaction pageLeft to rightBalanced
2 names
Resolves to: DUT
Human-GEM MAR04643CC BY 4.0Reference data
dUTP+waterdUMP+proton+diphosphate(3-)
Catalysed by DUT
Reaction pageLeft to rightBalancedEC 3.6.1.23nucleus
Human-GEM MAR08483CC BY 4.0Reference data
dUTP+waterdUMP+diphosphate(3-)+hydron
Catalysed by DUT
Reaction pageDirection not assertedBalanced
Rhea RHEA:10248CC BY 4.0Reference data