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Proteins/UNIPROT:O75874
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)..
Function from UniProtKB (O75874), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
257 statements
257 statements · 8 reference databases · Subject: IDH1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
isocitric acid+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Catalysed by IDH1
Reaction pageReversibleBalancedEC 1.1.1.42cytosol
Human-GEM MAR00710CC BY 4.0Reference data
isocitric acid+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Catalysed by IDH1
6 names
Resolves to: IDH1
Human-GEM MAR00712CC BY 4.0Reference data
D-threo-isocitrate+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:19629CC BY 4.0Reference data