Proteins/UNIPROT:Q92824

PCSK5

ProteinUNIPROT:Q92824

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Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins..

Function from UniProtKB (Q92824), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

33 statements

33 statements · 3 reference databases · Subject: PCSK5 · Sources: gene ontology, Hetionet, Reactome

Order

PCSK5 covaries with FCRL2ProteinHetionet hetionet:covaries:5125-79368Inferred only
AMH interacts with PCSK5ProteinHetionet hetionet:interacts:268-5125Inferred only
PCSK5 interacts with APPBP2ProteinHetionet hetionet:interacts:10513-5125Inferred only
ATN1 interacts with PCSK5ProteinHetionet hetionet:interacts:1822-5125Inferred only
CACNA1A interacts with PCSK5ProteinHetionet hetionet:interacts:5125-773Inferred only
ITGA6 interacts with PCSK5ProteinHetionet hetionet:interacts:3655-5125Inferred only
PCSK5 interacts with PMCHProteinHetionet hetionet:interacts:5125-5367Inferred only
PCSK5 interacts with PTPRMProteinHetionet hetionet:interacts:5125-5797Inferred only
PCSK5 interacts with RENProteinHetionet hetionet:interacts:5125-5972Inferred only
PCSK5 interacts with UBCProteinHetionet hetionet:interacts:5125-7316Inferred only
PCSK5 participates in Assembly of active LPL and LIPC lipase complexesPathwayReactome R-HSA-8963889Inferred only
PCSK5 participates in Expression and Processing of NeurotrophinsPathwayReactome R-HSA-9036866Inferred only

Show the remaining 21

PCSK5 participates in NGF processingPathwayReactome R-HSA-167060Inferred only
PCSK5 participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
PCSK5 participates in Plasma lipoprotein remodelingPathwayReactome R-HSA-8963899Inferred only
PCSK5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PCSK5 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
PCSK5 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
PCSK5 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
PCSK5 regulates negative regulation of low-density lipoprotein particle receptor catabolic processBiological processgene ontology Q92824|GO:0032804Inferred only
ACAT2 increases the expression of PCSK5ProteinHetionet hetionet:regulates:39-5125Inferred only
ASL increases the expression of PCSK5ProteinHetionet hetionet:regulates:435-5125Inferred only
B4GALT4 increases the expression of PCSK5ProteinHetionet hetionet:regulates:8702-5125Inferred only
HNF4A increases the expression of PCSK5ProteinHetionet hetionet:regulates:3172-5125Inferred only
ID2 increases the expression of PCSK5ProteinHetionet hetionet:regulates:3398-5125Inferred only
MSRA increases the expression of PCSK5ProteinHetionet hetionet:regulates:4482-5125Inferred only
NCOA3 increases the expression of PCSK5ProteinHetionet hetionet:regulates:8202-5125Inferred only
PNPO increases the expression of PCSK5ProteinHetionet hetionet:regulates:55163-5125Inferred only
PRPSAP2 increases the expression of PCSK5ProteinHetionet hetionet:regulates:5636-5125Inferred only
SMAD2 increases the expression of PCSK5ProteinHetionet hetionet:regulates:4087-5125Inferred only
TENT4A increases the expression of PCSK5ProteinHetionet hetionet:regulates:11044-5125Inferred only
XBP1 increases the expression of PCSK5ProteinHetionet hetionet:regulates:7494-5125Inferred only
XRCC5 increases the expression of PCSK5ProteinHetionet hetionet:regulates:7520-5125Inferred only

Other names

6 names

Resolves to: PCSK5

Also called: hPC6PC5PC6Proprotein convertase 5Proprotein convertase 6Subtilisin/kexin-like protease PC5

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