Loading the page.
Proteins/UNIPROT:P32321
Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP)..
Function from UniProtKB (P32321), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
293 statements
293 statements · 6 reference databases · Subject: DCTD · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
Catalysed by DCTD
Reaction pageLeft to rightBalancedEC 3.5.4.12cytosol
Human-GEM MAR04507CC BY 4.0Reference data
dCMP+water+hydrondUMP+ammonium
Catalysed by DCTD
Reaction pageLeft to rightBalanced
1 name
Resolves to: DCTD
CHEBI:57962+water+hydron5-hydroxymethyl-dUMP+ammonium
Catalysed by DCTD
Reaction pageLeft to rightBalanced
Rhea RHEA:77175CC BY 4.0Reference data