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Proteins/UNIPROT:Q9P035
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization..
Function from UniProtKB (Q9P035), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
344 statements
344 statements · 6 reference databases · Subject: HACD3 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
30 reactions
MAM00793c(2E)-octadecenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02193CC BY 4.0Reference data
MAM00777c(2E)-eicosenoyl-CoA+water
8 names
Resolves to: HACD3
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02203CC BY 4.0Reference data
MAM00776c(2E)-docosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02209CC BY 4.0Reference data
MAM00800c(2E)-tetracosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02213CC BY 4.0Reference data
MAM00783c(2E)-hexacosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02218CC BY 4.0Reference data
MAM00790cMAM00054c+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02261CC BY 4.0Reference data
MAM00778cMAM00044c+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02265CC BY 4.0Reference data
MAM00802cMAM00067c+water
Catalysed by HACD3 or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02269CC BY 4.0Reference data
MAM00700cwater+MAM03012c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02309CC BY 4.0Reference data
MAM00701cwater+MAM03013c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02319CC BY 4.0Reference data
MAM00709cwater+MAM03015c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02328CC BY 4.0Reference data
MAM00715cwater+MAM03016c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02336CC BY 4.0Reference data