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Proteins/UNIPROT:P06746
Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase..
Function from UniProtKB (P06746), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
281 statements
281 statements · 6 reference databases · Subject: POLB · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
4 reactions
3 names
Resolves to: POLB
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
DNA(n)+CHEBI:61560DNA(n+1)+diphosphate(3-)
Catalysed by TERT or REV3L or POLQ or DNTT or POLB or POLA1 or POLD1 or POLG or POLE or POLN or POLM or POLK and 3 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22508CC BY 4.0Reference data
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAa 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Catalysed by OGG1 or POLB or XRCC6 or XRCC5 or RPS3 or NTHL1 or ALKBH1 or NEIL3 or NEIL2 or NEIL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66592CC BY 4.0Reference data
a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNACHEBI:195195+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:76255CC BY 4.0Reference data