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Proteins/UNIPROT:Q53GL7
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA..
Function from UniProtKB (Q53GL7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
136 statements
136 statements · 6 reference databases · Subject: PARP10 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
4 reactions
4 names
Resolves to: PARP10
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data
L-lysyl-[protein]+NAD(1-)N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]+nicotinamide+hydron
Catalysed by PARP10 or PARP16 or SIRT6 or PARP11 or PARP3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58220CC BY 4.0Reference data