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Proteins/UNIPROT:Q86SQ9
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol..
Function from UniProtKB (Q86SQ9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
555 statements
555 statements · 6 reference databases · Subject: DHDDS · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt · Rows fetched: 300
3 reactions
16isopentenyl diphosphate+MAM03026cMAM01657c+16diphosphate(3-)
Catalysed by DHDDS
Reaction pageLeft to rightBalancedEC 2.5.1.87cytosol
Human-GEM MAR07254CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate+5isopentenyl diphosphateMAM01657r+5diphosphate(3-)
Catalysed by DHDDS
Reaction pageLeft to rightBalancedEC 2.5.1.87endoplasmic reticulum
6 names
Resolves to: DHDDS
nisopentenyl diphosphate+(2E,6E)-farnesyl diphosphatea di-trans,poly-cis-polyprenyl diphosphate+ndiphosphate(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53008CC BY 4.0Reference data