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Proteins/UNIPROT:P28749
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor..
Function from UniProtKB (P28749), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
111 statements
111 statements · 4 reference databases · Subject: RBL1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: RBL1