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Proteins/UNIPROT:P27707
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents..
Function from UniProtKB (P27707), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
287 statements
287 statements · 5 reference databases · Subject: DCK · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
2 names
Resolves to: DCK
Reaction pageLeft to rightBalancedEC 2.7.1.20mitochondrial matrix
Human-GEM MAR04083CC BY 4.0Reference data
ATP+2'-deoxycytidineADP+dCMP+proton
Catalysed by DCK
Reaction pageLeft to rightBalancedEC 2.7.1.74cytosol
Human-GEM MAR04513CC BY 4.0Reference data
ADP+dCMP+protonATP+2'-deoxycytidine
Catalysed by DCK
Reaction pageReversibleBalancedEC 2.7.1.145, 2.7.1.213, 2.7.1.74mitochondrial matrix
Human-GEM MAR08477CC BY 4.0Reference data
ADP+dCMP+protonATP+2'-deoxycytidine
Catalysed by DCK
Reaction pageReversibleBalancedEC 2.7.1.74nucleus
Human-GEM MAR08478CC BY 4.0Reference data
dCMP+proton+UDP2'-deoxycytidine+UTP
Catalysed by DCK
Reaction pageReversibleBalancedEC 2.7.1.74nucleus
Human-GEM MAR08479CC BY 4.0Reference data
2'-deoxyguanosine+ATP(4-)dGMP+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19201CC BY 4.0Reference data
2'-deoxycytidine+a ribonucleoside 5'-triphosphatedCMP+a ribonucleoside 5'-diphosphate+hydron
Catalysed by DCK
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20061CC BY 4.0Reference data
2'-deoxyadenosine+ATP(4-)CHEBI:58245+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:23452CC BY 4.0Reference data