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Proteins/UNIPROT:P46695
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment..
Function from UniProtKB (P46695), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
243 statements
243 statements · 4 reference databases · Subject: IER3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
10 names
Resolves to: IER3