Proteins/UNIPROT:P20594

NPR2

ProteinUNIPROT:P20594

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth..

Function from UniProtKB (P20594), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

acromesomelic dysplasia 1, Maroteaux type has a germline basis in NPR2DiseaseGenCC HGNC:7944|MONDO:0011275Inferred only
bone disorder has a germline basis in NPR2DiseaseGenCC HGNC:7944|MONDO:0005381Inferred only
short stature with nonspecific skeletal abnormalities 1 has a germline basis in NPR2DiseaseGenCC HGNC:7944|MONDO:0014551Inferred only
tall stature-scoliosis-macrodactyly of the great toes syndrome has a germline basis in NPR2DiseaseGenCC HGNC:7944|MONDO:0014401Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: NPR2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

NPR2 covaries with CD160ProteinHetionet hetionet:covaries:11126-4882Inferred only
EP300 interacts with NPR2ProteinHetionet hetionet:interacts:2033-4882Inferred only
HSP90AB1 interacts with NPR2ProteinHetionet hetionet:interacts:3326-4882Inferred only
NPPA interacts with NPR2ProteinHetionet hetionet:interacts:4878-4882Inferred only
NPPB interacts with NPR2ProteinHetionet hetionet:interacts:4879-4882Inferred only
NPPC interacts with NPR2ProteinHetionet hetionet:interacts:4880-4882Inferred only
NPR2 interacts with UBCProteinHetionet hetionet:interacts:4882-7316Inferred only
NPR2 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
NPR2 participates in FGFR3 signaling in chondrocyte proliferation and terminal differentiationPathwayWikiPathways WP4767Inferred only
NPR2 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
NPR2 participates in Physiological factorsPathwayReactome R-HSA-5578768Inferred only
NPR2 regulates regulation of blood pressureBiological processgene ontology P20594|GO:0008217Inferred only

Show the remaining 15

NPR2 increases the expression of ABCC5ProteinHetionet hetionet:regulates:4882-10057Inferred only
BIRC6 increases the expression of NPR2ProteinHetionet hetionet:regulates:57448-4882Inferred only
NPR2 decreases the expression of C2CD5ProteinHetionet hetionet:regulates:4882-9847Inferred only
CARD9 increases the expression of NPR2ProteinHetionet hetionet:regulates:64170-4882Inferred only
NPR2 increases the expression of CES1ProteinHetionet hetionet:regulates:4882-1066Inferred only
NPR2 increases the expression of CHMP6ProteinHetionet hetionet:regulates:4882-79643Inferred only
FBXL12 increases the expression of NPR2ProteinHetionet hetionet:regulates:54850-4882Inferred only
FPGS increases the expression of NPR2ProteinHetionet hetionet:regulates:2356-4882Inferred only
FZD5 increases the expression of NPR2ProteinHetionet hetionet:regulates:7855-4882Inferred only
NPR2 decreases the expression of HK1ProteinHetionet hetionet:regulates:4882-3098Inferred only
KDM3A increases the expression of NPR2ProteinHetionet hetionet:regulates:55818-4882Inferred only
MSRA increases the expression of NPR2ProteinHetionet hetionet:regulates:4482-4882Inferred only
NADSYN1 increases the expression of NPR2ProteinHetionet hetionet:regulates:55191-4882Inferred only
RUVBL2 increases the expression of NPR2ProteinHetionet hetionet:regulates:10856-4882Inferred only
NPR2 increases the expression of UBQLN2ProteinHetionet hetionet:regulates:4882-29978Inferred only

Reactions

3 reactions

ATP3',5'-cyclic AMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or ADCY2 or ADCY7 or ADCY4 or ADCY3 or ADCY10 or ADCY8 or NPR2 or ADCY9 or ADCY1 or ADCY5 or ADCY6
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04000

Other names

7 names

Resolves to: NPR2

Also called: ANP-BANPR-BANPRBAtrial natriuretic peptide receptor type BGC-BGuanylate cyclase BNPR-B

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