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Proteins/UNIPROT:Q9UHN1
Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA..
Function from UniProtKB (Q9UHN1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
129 statements
129 statements · 5 reference databases · Subject: POLG2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
5 names
Resolves to: POLG2
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data