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Proteins/UNIPROT:P27338
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine..
Function from UniProtKB (P27338), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
161 statements
161 statements · 8 reference databases · Subject: MAOB · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
23 reactions
water+N(tau)-methylhistamine+dioxygenproton+hydrogen peroxide+1-methylimidazole-4-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04430CC BY 4.0Reference data
2 names
Resolves to: MAOB
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04558CC BY 4.0Reference data
water+dioxygen+2-phenylethylamineproton+hydrogen peroxide+ammonium+2-phenylacetaldehyde
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR04682CC BY 4.0Reference data
water+dioxygen+tryptamineproton+hydrogen peroxide+indole-3-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.22cytosol
Human-GEM MAR06713CC BY 4.0Reference data
MAM01105c+dioxygenMAM00947c+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06719CC BY 4.0Reference data
CHEBI:28918+water+dioxygenMAM00726c+hydrogen peroxide+methylamine
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06745CC BY 4.0Reference data
water+N(2)-[4-(indol-3-yl)butanoyl]-L-glutamine+dioxygenMAM00820c+hydrogen peroxide+methylamine
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06747CC BY 4.0Reference data
water+(R)-normetanephrine+dioxygenMAM00820c+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06751CC BY 4.0Reference data
water+(R)-noradrenaline+dioxygenMAM00726c+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06752CC BY 4.0Reference data
dopamine+water+dioxygen3,4-dihydroxyphenylacetaldehyde+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06758CC BY 4.0Reference data
CHEBI:742324+water+dioxygenMAM00818c+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR06764CC BY 4.0Reference data
water+dioxygen+MAM03099cMAM01002c+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR06789CC BY 4.0Reference data