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Proteins/UNIPROT:O75354
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides..
Function from UniProtKB (O75354), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
238 statements
238 statements · 6 reference databases · Subject: ENTPD6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt
12 reactions
ADP+waterAMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6cytosol
Human-GEM MAR03998CC BY 4.0Reference data
4 names
Resolves to: ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6endoplasmic reticulum
Human-GEM MAR04059CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04060CC BY 4.0Reference data
GDP+waterGMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR04134CC BY 4.0Reference data
GTP+waterGDP+proton+phosphate(3-)
Catalysed by ENTPD2 or DNM2 or DNM1L or DNM1 or ENTPD1 or EFL1 or EEF1A1 or GFM2 or EEF2 or ENTPD3 or GFM1 or CANT1 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6extracellular space
Human-GEM MAR04136CC BY 4.0Reference data
water+CHEBI:17808proton+CHEBI:17202+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04342CC BY 4.0Reference data
ATP+2waterAMP+2proton+2phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR08474CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by CANT1 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.6Golgi apparatus
Human-GEM MAR08485CC BY 4.0Reference data
GDP+waterGMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or GBP1 or ENTPD1 or GBP7 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:22156CC BY 4.0Reference data
IDP+waterIMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or NUDT16 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:35207CC BY 4.0Reference data
a ribonucleoside 5'-diphosphate+waterCHEBI:58043+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or ENTPD8 or CANT1 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36799CC BY 4.0Reference data
UDP+waterUMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or ENTPD8 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:64876CC BY 4.0Reference data