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Proteins/UNIPROT:P24752
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism..
Function from UniProtKB (P24752), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
237 statements
237 statements · 7 reference databases · Subject: ACAT1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
CHEBI:15345+CHEBI:11469002CHEBI:15351
Catalysed by ACAT1
Reaction pageReversibleBalancedEC 2.3.1.9mitochondrial matrix
Human-GEM MAR03885CC BY 4.0Reference data
2propionyl-CoACHEBI:1146900+MAM03192m
Catalysed by ACAT1
Reaction pageReversibleBalancedEC 2.3.1.9mitochondrial matrix
Human-GEM MAR11486CC BY 4.0Reference data
4 names
Resolves to: ACAT1
Reaction pageReversibleBalanced
Rhea RHEA:21036CC BY 4.0Reference data
propanoyl-CoA+acetyl-CoA2-methyl-3-oxobutanoyl-CoA+coenzyme A(4-)
Catalysed by ACAT1
Reaction pageReversibleBalanced
Rhea RHEA:30719CC BY 4.0Reference data