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Proteins/UNIPROT:P35575
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels..
Function from UniProtKB (P35575), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
104 statements
104 statements · 7 reference databases · Subject: G6PC1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
D-glucopyranose 6-phosphate+waterD-glucose+phosphate(3-)
Catalysed by G6PC1 or G6PC3 or G6PC2
Reaction pageLeft to rightBalancedEC 3.1.3.9endoplasmic reticulum
Human-GEM MAR04521CC BY 4.0Reference data
D-glucose 6-phosphate+waterD-glucose+hydrogenphosphate
Catalysed by IMPA1 or
7 names
Resolves to: G6PC1
Reaction pageLeft to rightBalanced
Rhea RHEA:16689CC BY 4.0Reference data