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Proteins/UNIPROT:O15327
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival..
Function from UniProtKB (O15327), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
281 statements
281 statements · 3 reference databases · Subject: INPP4B · Sources: Hetionet, Reactome, WikiPathways
6 reactions
MAM00551c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.66cytosol
Human-GEM MAR06549CC BY 4.0Reference data
1 name
Resolves to: INPP4B
Human-GEM MAR06570CC BY 4.0Reference data
MAM00551n+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.66nucleus
Human-GEM MAR08810CC BY 4.0Reference data
CHEBI:57658+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+hydrogenphosphate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17193CC BY 4.0Reference data
CHEBI:83241+water1D-myo-inositol 3-phosphate+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:43388CC BY 4.0Reference data
CHEBI:58414+waterCHEBI:83242+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:43392CC BY 4.0Reference data