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Proteins/UNIPROT:Q9BTU6
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)..
Function from UniProtKB (Q9BTU6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
51 statements
51 statements · 5 reference databases · Subject: PI4K2A · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP+proton
Catalysed by PI4K2B or PI4KB or PI4K2A or PI4KA
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67cytosol
Human-GEM MAR06546CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)
1 name
Resolves to: PI4K2A
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67nucleus
Human-GEM MAR08830CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP(3-)+hydron
Catalysed by PI4KA or PI4K2B or PI4K2A or PI4KB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19877CC BY 4.0Reference data