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Proteins/UNIPROT:Q99758
Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity..
Function from UniProtKB (Q99758), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
91 statements
91 statements · 6 reference databases · Subject: ABCA3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea
5 reactions
ATP+water+MAM02715cADP+proton+MAM02715e+phosphate(3-)
Transported by ABCA3
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR09897CC BY 4.0Reference data
7 names
Resolves to: ABCA3
Reaction pageLeft to rightBalanced
Rhea RHEA:39051CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+ATP(4-)+watera 1,2-diacyl-sn-glycero-3-phosphocholine+ADP(3-)+hydrogenphosphate+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66272CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+ATP(4-)+water1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA3
Reaction pageLeft to rightBalanced
Rhea RHEA:66340CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)+ATP(4-)+watera 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66344CC BY 4.0Reference data