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Proteins/UNIPROT:O75072
Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable)..
Function from UniProtKB (O75072), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 rows
18 statements
18 statements · 4 reference databases · Subject: FKTN · Sources: gene ontology, Hetionet, Reactome, Rhea
1 reaction
3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein]+CDP-L-ribitol3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein]+CMP+hydron
Catalysed by FKTN
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36551CC BY 4.0Reference data
4 names
Resolves to: FKTN