Proteins/UNIPROT:Q8WXR4

MYO3B

ProteinUNIPROT:Q8WXR4

Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments..

Function from UniProtKB (Q8WXR4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: MYO3B · Sources: gene ontology, Hetionet, Reactome

Order

HSP90AA1 interacts with MYO3BProteinHetionet hetionet:interacts:140469-3320Inferred only
HSP90AB1 interacts with MYO3BProteinHetionet hetionet:interacts:140469-3326Inferred only
UBC interacts with MYO3BProteinHetionet hetionet:interacts:140469-7316Inferred only
MYO3B participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
MYO3B participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
MYO3B participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
MYO3B participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only
MYO3B regulates positive regulation of filopodium assemblyBiological processgene ontology Q8WXR4|GO:0051491Inferred only
MYO3B regulates regulation of actin filament lengthBiological processgene ontology Q8WXR4|GO:0030832Inferred only
MYO3B decreases the expression of ADGRE5ProteinHetionet hetionet:regulates:140469-976Inferred only
MYO3B increases the expression of CIAO3ProteinHetionet hetionet:regulates:140469-64428Inferred only
MYO3B decreases the expression of CKBProteinHetionet hetionet:regulates:140469-1152Inferred only

Show the remaining 11

MYO3B increases the expression of H2BC12ProteinHetionet hetionet:regulates:140469-85236Inferred only
MYO3B increases the expression of H2BC21ProteinHetionet hetionet:regulates:140469-8349Inferred only
MYO3B increases the expression of HBBProteinHetionet hetionet:regulates:140469-3043Inferred only
MYO3B decreases the expression of HOMER2ProteinHetionet hetionet:regulates:140469-9455Inferred only
MYO3B increases the expression of MSRAProteinHetionet hetionet:regulates:140469-4482Inferred only
MYO3B decreases the expression of SLC25A4ProteinHetionet hetionet:regulates:140469-291Inferred only
MYO3B increases the expression of SPP1ProteinHetionet hetionet:regulates:140469-6696Inferred only
MYO3B decreases the expression of STEAP1ProteinHetionet hetionet:regulates:140469-26872Inferred only
MYO3B decreases the expression of TCTAProteinHetionet hetionet:regulates:140469-6988Inferred only
MYO3B decreases the expression of UBE3CProteinHetionet hetionet:regulates:140469-9690Inferred only
MYO3B decreases the expression of ZMYM2ProteinHetionet hetionet:regulates:140469-7750Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

1 name

Resolves to: MYO3B

Also called: Myosin-IIIb

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