Proteins/UNIPROT:Q02487

DSC2

ProteinUNIPROT:Q02487

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation. Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function. Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity)..

Function from UniProtKB (Q02487), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

arrhythmogenic right ventricular dysplasia 11 has a germline basis in DSC2DiseaseGenCC HGNC:3036|MONDO:0012506Inferred only
familial isolated arrhythmogenic right ventricular dysplasia has a germline basis in DSC2DiseaseGenCC HGNC:3036|MONDO:0016342Inferred only

Statements

30 statements

30 statements · 4 reference databases · Subject: DSC2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

DSC2 interacts with DSG1ProteinHetionet hetionet:interacts:1824-1828Inferred only
DSC2 interacts with DSG2ProteinHetionet hetionet:interacts:1824-1829Inferred only
DSC2 interacts with JUPProteinHetionet hetionet:interacts:1824-3728Inferred only
DSC2 interacts with PKP2ProteinHetionet hetionet:interacts:1824-5318Inferred only
DSC2 interacts with PKP3ProteinHetionet hetionet:interacts:11187-1824Inferred only
DSC2 interacts with UBCProteinHetionet hetionet:interacts:1824-7316Inferred only
DSC2 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
DSC2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DSC2 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
DSC2 participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only
DSC2 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
DSC2 regulates positive regulation of p38MAPK cascadeBiological processgene ontology Q02487|GO:1900745Inferred only

Show the remaining 18

DSC2 regulates positive regulation of protein localizationBiological processgene ontology Q02487|GO:1903829Inferred only
DSC2 regulates positive regulation of wound healingBiological processgene ontology Q02487|GO:0090303Inferred only
DSC2 regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q02487|GO:0086091Inferred only
DSC2 regulates regulation of ventricular cardiac muscle cell action potentialBiological processgene ontology Q02487|GO:0098911Inferred only
ADGRG1 increases the expression of DSC2ProteinHetionet hetionet:regulates:9289-1824Inferred only
DDX49 increases the expression of DSC2ProteinHetionet hetionet:regulates:54555-1824Inferred only
FDX1 increases the expression of DSC2ProteinHetionet hetionet:regulates:2230-1824Inferred only
GNAI2 increases the expression of DSC2ProteinHetionet hetionet:regulates:2771-1824Inferred only
HEY1 increases the expression of DSC2ProteinHetionet hetionet:regulates:23462-1824Inferred only
HPRT1 increases the expression of DSC2ProteinHetionet hetionet:regulates:3251-1824Inferred only
MAP2K5 increases the expression of DSC2ProteinHetionet hetionet:regulates:5607-1824Inferred only
MAP3K8 increases the expression of DSC2ProteinHetionet hetionet:regulates:1326-1824Inferred only
MAP4K4 increases the expression of DSC2ProteinHetionet hetionet:regulates:9448-1824Inferred only
MSRA increases the expression of DSC2ProteinHetionet hetionet:regulates:4482-1824Inferred only
OVOL2 increases the expression of DSC2ProteinHetionet hetionet:regulates:58495-1824Inferred only
PDHX increases the expression of DSC2ProteinHetionet hetionet:regulates:8050-1824Inferred only
PRPF6 increases the expression of DSC2ProteinHetionet hetionet:regulates:24148-1824Inferred only
TRIM13 increases the expression of DSC2ProteinHetionet hetionet:regulates:10206-1824Inferred only

Other names

6 names

Resolves to: DSC2

Also called: Cadherin family member 2CDHF2Desmocollin-3Desmosomal glycoprotein IIDesmosomal glycoprotein IIIDSC3

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