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Proteins/UNIPROT:P00918
Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption..
Function from UniProtKB (P00918), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
211 statements
211 statements · 8 reference databases · Subject: CA2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
4 reactions
carbon dioxide+waterproton+hydrogencarbonate
Catalysed by CA2 or CA1 or CA7 or CA13
Reaction pageReversibleBalancedEC 4.2.1.1cytosol
Human-GEM MAR03955CC BY 4.0Reference data
carbon dioxide+waterproton+hydrogencarbonate
Catalysed by CA12
6 names
Resolves to: CA2
Reaction pageReversibleBalancedEC 4.2.1.1extracellular space
Human-GEM MAR05407CC BY 4.0Reference data
hydrogencarbonate+hydroncarbon dioxide+water
Catalysed by CA12 or CA1 or CA2 or CA4 or CA6 or CA5A or CA7 or CA9 or CA13 or CA14 or CA5B
Reaction pageReversibleBalanced
Rhea RHEA:10748CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:23056CC BY 4.0Reference data