S-sulfanylglutathione

Three steps

• propionic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by ETHE1, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by ETHE1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 5 routes

• butyric acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by ETHE1, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ETHE1, MPST, TST, AGXTmitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by ETHE1, SQOR, DHODH

• isocitric acidReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by ETHE1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• glutarateReach from here →
  1. Persulfide dioxygenase
  2. solute carrier organic anion transporter (glycocholate)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC22A24mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• (2R,3R)-tartrateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by ETHE1, SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane

• cis-aconitic acidReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by ETHE1, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• 3-oxopropanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• a carboxylic esterReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

  Catalysed by ETHE1, CP, PRDX6, CES2 and 4 more

• methylarsonateReach from here →
  1. Persulfide dioxygenase
  2. Glutathione: 5-HPETE oxidoreductase
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by ETHE1, GPX5, GPX1, GPX2 and 8 moremitochondrial matrix, cytosolOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. De novo synthesis of 2Fe2S

  Catalysed by ETHE1, NDUFAB1, FDXR, FXN and 4 moremitochondrial matrix, cytosol

• D-serineReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ETHE1, MPST, TST, SRRmitochondrial matrix, cytosol

• fatty acidReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ETHE1mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• a hydroperoxideReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O

  Catalysed by ETHE1, CP, PRDX6, PRDX5 and 4 more

• chenodeoxycholateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by ETHE1, PTGES, LANCL1, GSTM4 and 3 moreextracellular space, cytosolOne of 2 routes

• glyoxylateReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by ETHE1, SLC25A10, CLYBLmitochondrial matrix, cytosol

• CHEBI:37946Reach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. aryl sulfotransferase (dopamine)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• (R)-lactic acidReach from here →
  1. Persulfide dioxygenase
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-Lactoylglutathione hydrolase

  Catalysed by ETHE1, GLO1, GLOD4, HAGH and 1 moremitochondrial matrix, cytosolOne of 3 routes

• (S)-lactic acidReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin A2 (cytosol to extracellular)
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• 2-iminopropanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by ETHE1, MPST, TST, RIDAmitochondrial matrix, cytosol

• phosphoenolpyruvic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by ETHE1, MPST, TST, PKM and 1 moremitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by ETHE1, MPST, TST, NPLmitochondrial matrix, cytosol

• L-ornithineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• N-methylserotoninReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, INMTmitochondrial matrix, extracellular space, cytosol

• Cu(+)Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by ETHE1, CLIC1, GSTO1, GSTO2 and 1 moreinner side of the membrane, outer side of the membrane

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, MAOA and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by ETHE1, FAAHmitochondrial matrix, extracellular space, cytosol

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by ETHE1, SQOR, NQO2

• malonaldehydeReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by ETHE1, SLCO2A1, TBXAS1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DIO1 and 1 moremitochondrial matrix, extracellular space, cytosol

• a 3-acylpyruvateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ETHE1, MPST, TST, FAHD1mitochondrial matrix, cytosol

• glycineReach from here →
  1. Persulfide dioxygenase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 hydrolysis

  Catalysed by ETHE1, LTC4Smitochondrial matrix, cytosolOne of 12 routes

• (S)-malyl-CoAReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by ETHE1, SLC25A10, SUCLG1, SUCLA2mitochondrial matrix, cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by ETHE1, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, extracellular space, cytosol

• choloyl-CoAReach from here →
  1. Persulfide dioxygenase
  2. solute carrier organic anion transporter (cholate)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC27A5mitochondrial matrix, extracellular space, cytosol

• 15-oxoprostaglandin E2Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, HPGDmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin E1Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

  Catalysed by ETHE1, SLCO2A1, CBR3, CBR1 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 15-oxoprostaglandin D2Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. Glutathione: 15-HPETE oxidoreductase
  3. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by ETHE1, ALOX5, ALOX15, ALOX12mitochondrial matrix, extracellular space, cytosol

• thromboxane A2Reach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. thromboxane A2 hydrolysis

  Catalysed by ETHE1, SLCO1B1mitochondrial matrix, extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by ETHE1, ALOX15B, ALOX15, ALOX12mitochondrial matrix, extracellular space, cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by ETHE1, ALOX5mitochondrial matrix, extracellular space, cytosol