choloyl-CoA

1. choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by NUDT19, NUDT7

1. choloyl-CoA + glycine = glycocholate + CoA + H(+)

Catalysed by BAAT

1. choloyl-CoA + H2O = cholate + CoA + H(+)

Catalysed by ACOT8, BAAT

1. choloyl-CoA + taurine = taurocholate + CoA + H(+)

Catalysed by BAAT

1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
2. solute carrier organic anion transporter (glycocholate)

Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

1. choloyl-CoA + H2O = cholate + CoA + H(+)
2. Cholate:CoA ligase (AMP-forming)

Catalysed by ACOT8, BAAT, SLC27A2, SLC27A5endoplasmic reticulum

1. choloyl-CoA + H2O = cholate + CoA + H(+)
2. Cholate:CoA ligase (AMP-forming)
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by ACOT8, BAAT, SLC27A2, SLC27A5endoplasmic reticulum, peroxisomeOne of 6 routes

1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O