Compound

15-oxoprostaglandin E1

Conjugate base of 15-dehydro-prostaglandin E1.

Definition from ChEBI (CHEBI:57401), read 2026-09-23. CC BY 4.0.

CHEBI:57401ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of 15-oxoprostaglandin E1 — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C20H31O5
Mass: 351.463 g/mol
Charge: -1
InChIKey: VXPBDCBTMSKCKZ-XQHNHVHJSA-M
SMILES: CCCCCC(=O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: 15-oxoprostaglandin E1 · Sources: Human-GEM, Rhea

Order

15-oxoprostaglandin E1 is converted to prostaglandin E1CompoundRhea RHEA:16477Inferred only
15-oxoprostaglandin E1 is converted to prostaglandin E1CompoundHuman-GEM MAR08546Inferred only
prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundRhea RHEA:11636Inferred only
prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundRhea RHEA:16477Inferred only
prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundHuman-GEM MAR08546Inferred only
15-oxoprostaglandin E1 is converted to prostaglandin E1CompoundRhea RHEA:11636Inferred only
15-oxoprostaglandin E1 is a substrate of CBR1ProteinRhea RHEA:11636Inferred only
15-oxoprostaglandin E1 is a substrate of CBR1ProteinHuman-GEM MAR08546Inferred only
15-oxoprostaglandin E1 is a substrate of CBR3ProteinHuman-GEM MAR08546Inferred only
15-oxoprostaglandin E1 is a substrate of DHRS4ProteinHuman-GEM MAR08546Inferred only
15-oxoprostaglandin E1 is a substrate of HPGDProteinRhea RHEA:16477Inferred only

Reactions

5 reactions

11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate+15-oxoprostaglandin E1+MAM00014x+(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate+MAM00254c+MAM00254m+MAM00254x+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00274c+MAM00274r+MAM00276c+MAM00277c+MAM00278c+MAM00280c+MAM00282c+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+MAM00293c+MAM00297c+MAM00298c+MAM00304c+MAM00306c+MAM00308c+MAM00318c+MAM00318r+MAM00319c+MAM00320c+MAM00321c+MAM00322c+MAM00323c+MAM00323r+MAM00324r+MAM00327c+MAM00327r+MAM00328c+MAM00328r+MAM00333r+12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate+(13S)-hydroxy-(9Z,11E)-octadecadienoate+MAM00338c+MAM00340c+MAM00352r+13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00364c+14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate+MAM00378c+MAM00382c+15-deoxy-Delta(12,14)-prostaglandin J2+MAM00384c+MAM00386c+MAM00386r+MAM00386x+MAM00387c+MAM00387r+MAM00387x+MAM00388c+MAM00388r+MAM00388x+MAM00389c+MAM00389r+MAM00389x+15-oxoprostaglandin F2alpha+MAM00395c+16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00398x+17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00424m+MAM00425x+MAM00426c+18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00430c+MAM00590c+MAM00595c+MAM00595r+MAM00598c+MAM00598r+MAM00602c+MAM00687m+MAM00687x+MAM01038n+MAM01039x+MAM01041n+MAM01046c+MAM01047c+MAM01049c+MAM01050c+MAM01051c+5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+MAM01055c+MAM01120c+MAM01120r+MAM01122c+MAM01122r+MAM01150c+MAM01150m+MAM01150x+MAM01153c+MAM01153m+MAM01153r+MAM01153x+MAM01167c+MAM01168r+MAM01171c+MAM01171m+MAM01171x+MAM01172c+MAM01172m+MAM01172x+7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM01202c+MAM01208c+8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+MAM01210c+MAM01213c+MAM01239c+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+MAM02368c+MAM02395n+MAM02395r+MAM02395x+MAM02396r+MAM02396x+malonaldehyde+MAM02538c+MAM02538n+MAM02649m+MAM02649x+prostaglandin E2+prostaglandin E3+prostaglandin H1+prostaglandin J2+MAM02797c+MAM02798c+MAM02799c+MAM02851c+MAM02852c+MAM02862c+MAM02863c+MAM02864c+MAM03055c+MAM03055r+MAM03055x+MAM03056cMAM10003e
Reaction pageLeft to rightBalance undeterminableGO:0005829, GO:0005777, GO:0005759, GO:0005783, GO:0005634, GO:0005615
Human-GEM MAR00036CC BY 4.0Reference data
15-oxoprostaglandin E1+proton+NADPH(4-)NADP(3-)+prostaglandin E1
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.197GO:0005829
Human-GEM MAR08546CC BY 4.0Reference data
prostaglandin E1+NADP(3-)15-oxoprostaglandin E1+NADPH(4-)+hydron
Catalysed by CBR1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11636CC BY 4.0Reference data
prostaglandin E1+NAD(1-)15-oxoprostaglandin E1+NADH(2-)+hydron
Catalysed by HPGD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16477CC BY 4.0Reference data
CHEBI:133408+NADP(3-)15-oxoprostaglandin E1+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:50584CC BY 4.0Reference data

Other names

6 names

Resolves to: 15-oxoprostaglandin E1

Also called: 15-dehydro-prostaglandin E1 anion15-keto-PGE115-oxo-PGE115-oxo-prostaglandin E1
Systematic name: (13E)-11alpha-hydroxy-9,15-dioxoprost-13-en-1-oate(13E)-11α-hydroxy-9,15-dioxoprost-13-en-1-oate