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Proteins/UNIPROT:O95050
Functions as a thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds..
Function from UniProtKB (O95050), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 5 reference databases · Subject: INMT · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
S-adenosyl-L-methionine+serotoninproton+N-methylserotonin+CHEBI:16680
Catalysed by INMT
Reaction pageLeft to rightBalancedEC 2.1.1.49cytosol
Human-GEM MAR04555CC BY 4.0Reference data
N-methylserotonin+S-adenosyl-L-methionineMAM01408c+2proton+CHEBI:16680
Catalysed by INMT
6 names
Resolves to: INMT
Human-GEM MAR04556CC BY 4.0Reference data
S-adenosyl-L-methionine+tryptamineproton+N-methyltryptamine+CHEBI:16680
Catalysed by INMT
Reaction pageLeft to rightBalancedEC 2.1.1.49cytosol
Human-GEM MAR06711CC BY 4.0Reference data
S-adenosyl-L-methionine+MAM03099cproton+MAM02606c+CHEBI:16680
Catalysed by COMT or LRTOMT or INMT
Reaction pageLeft to rightBalancedEC 2.1.1.49, 2.1.1.6cytosol
Human-GEM MAR06788CC BY 4.0Reference data
dimethyl sulfide+S-adenosyl-L-methioninetrimethylsulfonium+S-adenosyl-L-homocysteine
Catalysed by INMT
Reaction pageDirection not assertedBalanced
Rhea RHEA:19613CC BY 4.0Reference data
a primary amine+S-adenosyl-L-methioninea methylated primary amine+S-adenosyl-L-homocysteine+hydron
Catalysed by INMT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23136CC BY 4.0Reference data
a secondary amine+S-adenosyl-L-methioninea methylated secondary amine+S-adenosyl-L-homocysteine+hydron
Catalysed by INMT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53924CC BY 4.0Reference data
a tertiary amine+S-adenosyl-L-methioninea methylated tertiary amine+S-adenosyl-L-homocysteine+hydron
Catalysed by INMT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53928CC BY 4.0Reference data