L-tryptophan

Three steps

• 3-iodo-L-thyronineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by SLC7A5, MOCOS, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC7A5, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by SLC7A5, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• serotonin O-sulfateReach from here →
  1. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)
  2. 5-Hydroxy-L-tryptophan decarboxy-lyase
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TPH1, TPH2, DDC, SULT1A3 and 1 morecytosol

• L-thyronineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by SLC7A5, MOCOS, DIO3extracellular space, cytosol

• thyronamineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by SLC7A5, MOCOS, DIO3extracellular space, cytosol

• 3'-iodothyronamineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by SLC7A5, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC7A5, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC7A5, MOCOS, DIO3extracellular space, cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by SLC7A5, MOCOS, DIO3extracellular space, cytosol

• L-homocysteine thiolactoneReach from here →
  1. transport of methionine and tryptophan (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP = L-homocysteine thiolactone + AMP + diphosphate

  Catalysed by SLC7A5, BHMT2, MARS1extracellular space, cytosol

• L-homocysteinyl-AMPReach from here →
  1. transport of methionine and tryptophan (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP + H(+) = L-homocysteinyl-AMP + diphosphate

  Catalysed by SLC7A5, BHMT2, MARS1extracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC7A5, BAAT, HADHA, ACADVL and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC7A5, BAAT, HADHA, ACADVL and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC7A5, BAAT, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC7A5, BAAT, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLC7A5, GSS, GSTP1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC7A5, SULT2A1extracellular space, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC7A5, BAAT, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC7A5extracellular space, cytosol

• a quinolReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by SLC7A5, GSS, SQORextracellular space, cytosolOne of 4 routes

• imidazole-4-acetaldehydeReach from here →
  1. transport of histidine and tryptophan (cytosol to extracellular)
  2. L-histidine carboxy-lyase (histamine-forming)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLC7A6, HDC, AOC2, AOC1 and 1 moreextracellular space, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC6A14, SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC7A5, BAAT, ACSM4, ACSM1 and 4 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• selenomethionineReach from here →
  1. transport of threonine and tryptophan (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by SLC7A5, SDS, SDSL, CTHextracellular space, cytosol

• CHEBI:27760Reach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SLC7A5, SCLY, CTHextracellular space, cytosolOne of 2 routes

• elaidic acidReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC7A5, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• 5(S)-HETEReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC7A5, GSS, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes

• (2-hydroxyphenyl)acetic acidReach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC7A5, GOT2, TAT, HPDextracellular space, cytosol, mitochondrial matrix

• 3-mercaptolactic acidReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by SLC7A5, GOT2, GOT1, LDHB and 3 moreextracellular space, cytosol

• CHEBI:28701Reach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC7A5, BAAT, ACAA1, SCP2 and 1 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• 3-disulfanyl-L-alanineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A5, SLC7A9, SLC3A1, CTHextracellular space, cytosol

• CHEBI:28862Reach from here →
  1. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)
  2. glycyl-tRNA(gly) phosphorylation
  3. 2'-deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by WARS1, TXN, RRM1, RRM2 and 2 morecytosol

• a dicarboxylateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. Hippurate (Benzoylglycinate) Formation
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC7A5, SLC22A6, SLC22A8extracellular space, cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-ascorbic acidReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLC7A5, GSS, CLIC1, GSTO1 and 1 moreextracellular space, cytosol

• Ca(2+)Reach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  3. Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)

  Catalysed by SLC7A5, SLC1A1, SLC24A1, SLC24A5 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. transport of leucine and tryptophan (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by SLC7A5, BCAT2, BCKDHA, BCKDHBextracellular space, cytosol, mitochondrial matrix

• hypoioditeReach from here →
  1. transport of tryptophan and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC7A5, TPO, MPO, LPOextracellular space, cytosol

• a thiolReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by SLC7A5, CTH, SUMF1extracellular space, cytosol

• hydrogenselenideReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by SLC7A5, MOCOS, SCLYextracellular space, cytosol

• phosphocholineReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC6A14, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• cholateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC7A5, GSS, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 3 routes

• glycolateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. glycolate:NADP+ oxidoreductase

  Catalysed by SLC7A5, DAO, GRHPRextracellular space, cytosol, peroxisomeOne of 3 routes

• D-aspartateReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A5, SLC1A1, SLC1A7, SLC1A3 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  2. arylformamidase (L-formylkynurenine)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by IDO1, TDO2, IDO2, AFMID and 3 morecytosol, extracellular spaceOne of 11 routes

• 3-acetamidopropanalReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. Transport by Y+Lat-2 into Extracellular Space
  3. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by SLC7A6, SLC3A2, PAOX, SMOXextracellular space, cytosolOne of 2 routes

• oxalateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by SLC7A5, AADAT, HAO1extracellular space, cytosolOne of 5 routes

• anthranilic acidReach from here →
  1. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  2. arylformamidase (L-formylkynurenine)
  3. L-Kynurenine hydrolase

  Catalysed by IDO1, TDO2, IDO2, AFMID and 1 morecytosolOne of 2 routes

• propionic acidReach from here →
  1. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  2. arylformamidase (L-formylkynurenine)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by IDO1, TDO2, IDO2, AFMID and 3 morecytosol, extracellular spaceOne of 4 routes